Abstract: The diagnosis of clinico-radiologic syndromes is based on a set of characteristics of comprehensive evaluation of the factors such as cranial imaging and clinical manifestations. In this article, we focus on the three clinico-radiologic disorders (posterior reversible encephalopath syndrome, clinically mild encephalitis/encephalopathy with a reversible splenial lesion of corpus callosum, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids). In the present issue of the Journal, the cases has been reported. Although magnetic resonance is a revolution in medical imaging, but for doctors, imaging technology will never replace the detailed clinical history and physical examination. Their combination will improve to study the causes and pathogenesis of disorders. Early diagnosis and early treatment will avoid or reduce neurological sequelae of patients.